Does social distancing for too long and with enormous caution have an effect on social anxiety?

Yes, you see it everywhere.  Lots of people want to commit suicide now cause they can not deal with it.

In the majority of people,it's yes.

You also have suicides going up along with crime.

well as far as isolation is concerned, i'd certainly say yes, someone will pay the price in terms of anxiety, because too much isolation can generate it. as for the 'enormous caution' i wouldn't know, it is an indefinite and personal concept, probably for those who have emphasized an already unhealthy hygienism or hypochondria or have acquired it, yes too.

Differently to different people. 

Absolutely.  Distrust builds.  Fear easily sets in. touch, upbeat hugs.  Actually, don't we all?

i would hope not

Of course it does                   .